Koanolide A, antiproliferative germacrane-type sesquiterpene lactone from Koanophyllongibbosum.

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dc.contributor.authorQuírico Castillo
dc.date.accessioned2026-01-27T19:19:53Z
dc.date.available2026-01-27T19:19:53Z
dc.date.issued2019-06
dc.description.abstractA new germacrane-type sesquiterpene lactone, koanolide A (1), was isolated from the aerial parts of Koanophyllon gibbosum. The new structure was elucidated using spectroscopic and spectrometric data analyses, including 1D and 2D NMR. The absolute configuration of compound 1 was established by X-ray crystallography. The antiproliferative activity of 1 was studied in a panel of six representative human solid tumor cell lines and showed GI50 values ranging from 0.34 to 20 μM.
dc.identifier.citationCastillo, Q., & Lora, J. (2019). Koanolide A, antiproliferative germacrane-type sesquiterpene lactone from Koanophyllon gibbosum. Tetrahedron Letters, 60(25), 1640–1642.
dc.identifier.urihttps://repositoriovip.uasd.edu.do/handle/123456789/1547
dc.language.isoen
dc.titleKoanolide A, antiproliferative germacrane-type sesquiterpene lactone from Koanophyllongibbosum.
dc.typeArticle
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