Koanolide A, antiproliferative germacrane-type sesquiterpene lactone from Koanophyllongibbosum.
Koanolide A, antiproliferative germacrane-type sesquiterpene lactone from Koanophyllongibbosum.
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Date
2019-06
Authors
Quírico Castillo
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Abstract
A new germacrane-type sesquiterpene lactone, koanolide A (1), was isolated from the aerial parts of Koanophyllon gibbosum. The new structure was elucidated using spectroscopic and spectrometric data analyses, including 1D and 2D NMR. The absolute configuration of compound 1 was established by X-ray crystallography. The antiproliferative activity of 1 was studied in a panel of six representative human solid tumor cell lines and showed GI50 values ranging from 0.34 to 20 μM.
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Castillo, Q., & Lora, J. (2019). Koanolide A, antiproliferative germacrane-type sesquiterpene lactone from Koanophyllon gibbosum. Tetrahedron Letters, 60(25), 1640–1642.