Rapid indirect hippocampal volumetry using the XYZ geo method: A useful tool in the diagnosis of cognitive impairment
Rapid indirect hippocampal volumetry using the XYZ geo method: A useful tool in the diagnosis of cognitive impairment
Date
2024-01-10
Authors
Santiago Valenzuela Sosa
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Abstract
Objectives: to compare and validate the doses determined according to the novel method
for calculating doses in radiosurgery called the Sosa Model (MS) with the dose protocols
of national and international institutions. Material and Method: retrospective study on 403
tumor lesions of different histology found in 172 patients treated by radiosurgery at the
Gamma Knife Dominican Center (CGKD), using MRI images of 1.5 and 3.0 Tesla with
protocol for neuronavigation. In MS, the Sosa Score (SS) is obtained by adding 3 scores to
a constant of 10Gy: Volume Score (VS), Radioresistance Score (RS), Eloquence Score (ES)
of the lesion, complying with the formula that supports it. : SS= VS+RS+ES+10. Using the
Wilcoxon Signed-Rank Test, it was compared with the conventional doses used in the CGKD,
which are similar to those used internationally. Results: most lesions received between 12 and
24 Gy, calculated by both methods. Of the meningiomas treated in the CGKD, 65% received
a dose of 12 to 14 Gy. Most of the doses suggested by the MS were between 15 and 18 Gy.
On average, metastases treated in CGKD received between 16 and 24 Gy (220 of 247, 89%).
The doses recommended by the MS were very close, ranging between 15 and 21 Gy (232 of
247, 93.9%). In Non-Functional Pituitary Adenomas, the MS (17-18 Gy) yields doses above
those of the CGKD (12-16 Gy) since it does not include adaptations to protect the visual
pathway. In Functional Pituitary Adenomas, MS falls below the particularly high doses (25
to 35 Gy) internationally recommended. The Acoustic Neuromas all received between 12
and 13 Gy in the CGKD and most of the doses recommended by the MS were between 14
and 15 Gy. Conclusions: Comparing the doses used by CGKD and those recommended by
MS, there is a close proximity when it comes to Acoustic Neuromas and Metastases, but an
important difference when it comes to Adenomas and Meningiomas. When applying the
Wilcoxon Signed Rank Test to the 403 lesions studied, the mean difference between the two
dose calculation systems was 0.23 Gy (95% CI: -0.127-0.60)
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Valenzuela Sosa, S. (2024). Rapid indirect hippocampal volumetry using the XYZ geo method: A useful tool in the diagnosis of cognitive impairment. Universidad Autónoma de Santo Domingo (UASD).