Real World KINDLE-Latin America Subset data on treatment patterns and clinical outcomes in patients with stage III Non-Small-Cell Lung Cancer
Real World KINDLE-Latin America Subset data on treatment patterns and clinical outcomes in patients with stage III Non-Small-Cell Lung Cancer
Date
2022-07-04
Authors
Adrián Puello
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Abstract
Introduction: Stage III non- small- cell lung cancer (NSCLC) management is challenging
given the heterogeneous nature of the disease. The LATAM subset of the real- world, global
KINDLE study reported the treatment patterns and clinical outcomes for LATAM from
the pre- immuno- oncology era.Methods: The study was conducted in seven countries
(Argentina, Chile, Colombia, Dominican Republic, Mexico, Peru and Uruguay) in stage III
NSCLC (American Joint Committee on Cancer, 7th edition) diagnosed between January
2013 and December 2017. Retrospective data from patients’ medical records (index date to
the end of follow- up) were collected. Summary statistics, Kaplan– Meier sur-vival estimates
and a two- sided 95% confidence interval (CI) were provided. Cox proportional hazard
model was used for univariate and multi- variateanalyses.Results: A total of 231 patients
was enrolled, the median age was 65.0 years (range 21.0– 89.0), 60.6% were males, 76.6%
had smoking history, 64.0% had ad-enocarcinoma and 28.7% underwent curative resection.
Multiple treatment regi-mens (>25) were used; chemotherapy alone was the most common
(24.8%). The overall median progression- free survival (mPFS) and median overall survival
(mOS) were 14.8 months (95% CI, 12.1– 18.6) and 48.6 months (95% CI, 34.7 to not
calculable). Significantly better mPFS and mOS were observed for stage IIIA with curative
surgery and resectabletumours and stage IIIB with an Eastern Cooperative Oncology Group
score of 0/1, female gender, resectabletumours, ad-enocarcinoma and curative surgery (p
< 0.05).Conclusion: Results show diversity in treatment practices and the correspond-ing
clinical outcomes in stage III NSCLC. There is a need to streamline treatment selection and
sequencing to decrease relapse rates after initial therapy.
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Citation
Puello, A. (2022, julio 4). Real world KINDLE-Latin America subset data on treatment patterns and clinical outcomes in patients with stage III non-small-cell lung cancer. Universidad Autónoma de Santo Domingo (UASD).