Simulations of surface charge density changes during the untreated solid tumour growth
Simulations of surface charge density changes during the untreated solid tumour growth
Date
2022-11-30
Authors
Narciso Villar Goris
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Abstract
Understanding untreated tumour growth kinetics and its intrinsic behaviour is interesting
and intriguing. The aim of this study is to propose an approximate analytical expression that
allows us to simulate changes in surface charge density at the cancer-surrounding healthy
tissue interface during the untreated solid tumour growth. For this, the Gompertz and
Poisson equations are used. Simulations reveal that the unperturbed solid tumour growth is
closely related to changes in the surface charge density over time between the tumour and the
surrounding healthy tissue. Furthermore, the unperturbed solid tumour growth is governed
by temporal changes in this surface charge density. It is concluded that results corroborate
the correspondence between the electrical and physiological parameters in the untreated
cancer, which may have an essential role in its growth, progression, metastasis and protection
against immune system attack and anti-cancer therapies. In addition, the knowledge of
surface charge density changes at the cancer-surrounding healthy tissue interface may be
relevant when redesigning the molecules in chemotherapy and immunotherapy taking into
account their polarities. This can also be true in the design of completely novel therapies.
Description
Keywords
Física Médica, Física
Citation
Bory Prevez H et al. 2022 Simulations of surface charge density changes during the untreated solid tumour growth. R. Soc. Open Sci.