ESCAPE pain trial –The effects of Curcumin in pain relief in women diagnosed with primary dysmenorrhea: A triple-blinded, placebo-controlled, phase II, randomized clinical trial protocol
ESCAPE pain trial –The effects of Curcumin in pain relief in women diagnosed with primary dysmenorrhea: A triple-blinded, placebo-controlled, phase II, randomized clinical trial protocol
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Date
2020-08-12
Authors
Vahid Nouri Kandany
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Abstract
Primary dysmenorrhea affects many women, being a major cause of absenteeism and reduced productivity at work and at school. Although non-steroidal anti-inflammatory drugs (NSAIDs) are a good treatment option, up to 18% of women show no response or present allergic reactions and adverse events. Curcumin has antispasmodic, antinociceptive, and both specific and nonspecific anti-inflammatory effects, with good tolerability and safety. To date, no previous trial involving curcumin and dysmenorrhea pain has been performed. Therefore, our main goal is to assess the efficacy of curcumin for pain relief among women with primary dysmenorrhea, along with determining curcumin’s adverse effects and tolerability profile.
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ESCAPE pain trial - The effects of Curcumin in pain relief in women diagnosed with primary dysmenorrhea: A triple blinded, placebo-controlled, phase II, randomized clinical trial protocol. (2020). Principles and Practice of Clinical Research, 6(2).