Secondary metabolites from Pterocaulonalo pecuroides and their antiproliferative activities.

Simple item page
dc.contributor.authorQuírico Castillo
dc.date.accessioned2026-01-27T19:22:54Z
dc.date.available2026-01-27T19:22:54Z
dc.date.issued2019
dc.description.abstractTo isolate secondary metabolites from the aerial parts of Pterocaulon alopecuroides, elucidate their structures and evaluate their antiproliferative activities on selected human cancer cell lines. Materials and Methods: The ethanolic extract of P. alopecuroides afforded five compounds, which were characterized using spectroscopic techniques and by comparison with data from the literature. Antiproliferative activities of all isolates were evaluated. Results: The compounds 7-(2,3-dihydroxy-3-methylbutoxy)-6-methoxycoumarin (1), 5,6-methylenedioxy- 7-(2,3-dihydroxy-3-methylbutoxy) coumarin (2), Dihydrokaempferol (3), 5,7,4´-trihydroxy- 6-(α,α-dimethylallyl)dihydroflavonol (4) and 5,4´-dihydroxy-7-(γ,γ-dimethylallyloxy)dihydroflavonol (5) were isolated. The antiproliferative activity of all compounds was evaluated in a panel of six human solid tumor cell lines showing GI50 values for the most active compounds in the low micromolar range. Conclusion: Compound 2 is reported for first time from P. alopecuroides. Isolated coumarins show no antiproliferative activity, whilst among flavonoids compound 5 showed the best antiproliferative activity.
dc.identifier.citationCastillo, Q. (2019). Secondary metabolites from Pterocaulon alopecuroides and their antiproliferative activities. Pharmacognosy Journal, 11(3), 488–492.
dc.identifier.urihttps://repositoriovip.uasd.edu.do/handle/123456789/1548
dc.language.isoen
dc.titleSecondary metabolites from Pterocaulonalo pecuroides and their antiproliferative activities.
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Secondary metabolites from Pterocaulonalo pecuroides and their antiproliferative activities..pdf
Size:
5.17 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.6 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
Artículos FC IQUASD