The Helicobacter pylori Genome Projects: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

Simple item page
dc.contributor.authorModesto Cruz
dc.date.accessioned2025-09-11T19:58:16Z
dc.date.available2025-09-11T19:58:16Z
dc.date.issued2023-12-11
dc.descriptionPublicado por la revista: Nature Communications. 14: 8184 (2023)
dc.description.abstractHelicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics.
dc.identifier.citationCruz, M. (2023). The Helicobacter pylori Genome Projects: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes. Nature Communications, 14, 8184.
dc.identifier.urihttps://repositoriovip.uasd.edu.do/handle/123456789/1063
dc.language.isoen
dc.relation.ispartofseries2024; 12
dc.titleThe Helicobacter pylori Genome Projects: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
The Helicobacter pylori Genome Project_ insights into H. pylori population structure from analysis of a worldwide collection of complete genomes.pdf
Size:
1.99 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.6 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
Articulo IMPA